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Consente operatori sanitari per identificare la stratificazione del rischio di SMM
Smoldering Multiple Myeloma (SMM) app is a mobile application allowing healthcare professionals to calculate the SMM risk level on the basis of an algorithm combining the following parameters:
(1) Percentage of bone marrow plasma cell (BMPC) infiltration;
(2) Immunoglobulin level (based on either IgG level, IgA level, or Bence Jones (BJ) protein level);
(3) Percentage of phenotypically aberrant plasma cells in the bone marrow plasma cell compartment;
(4) Percentage of reductions in one or two uninvolved immunoglobulins.
The way in which the above-listed parameters should be combined and the threshold values which they require are described as follows in the paper “Lenalidomide plus dexamethasone for high-risk Smoldering Multiple Myeloma”, published by Mateos (et al.) in the New England Journal of Medicine (2013, 369:438-447):
“High-risk disease was defined as plasma-cell bone marrow infiltration of at least 10% and a monoclonal component (defined as an IgG level of ≥3 g per deciliter, an IgA level of ≥2 g per deciliter, or a urinary Bence Jones protein level of >1 g per 24 hours) or only one of the two criteria described above, plus at least 95% phenotypically aberrant plasma cells in the bone marrow plasma-cell compartment, with reductions in one or two uninvolved immunoglobulins of more than 25%, as compared with normal values”.
On the basis of the above-described parameters and values, resulting from blood tests and urinary tests (BJ index), the SMM app will calculate whether a patient is “high risk SMM”, “not high risk SMM”, or has progressed to MM (Multiple Myeloma).
Last updated on Jun 25, 2020
Minor enhancements and updated logo
Caricata da
Carlos Sanchez
È necessario Android
Android 4.4+
Categoria
Segnala
Smoldering Multiple Myeloma
1.03 by Pethema
Jun 25, 2020